The Ministry of Education and Science of the Russian Federation started systemic foresight activities aimed at different issues related to science, technology and innovation. Following development of national S&T priorities (see [1]), it launched a study to identify pri-ority areas for innovation development for a pilot region – the Republic of Bashkortostan. The methodologies and design of the pro-ject are to be used as a pattern for other regions, whereas the results obtained contribute to the development of the regional programme of social and economic development.