The RegStrat-project explored new ways of combining foresight with other strategic policy intelligence (SPI) tools, such as technology assessment, evaluation, benchmarking and innovation auditing, to advise regional decision-makers along the whole policycycle on the best ways to apply these tools to design and implement regional research, technological development and innovation (RTDI) policies and programmes, and related RTDI investment strategies. This approach is tested in pilot applications in the six participating regions. Based on this, a guide is developed to support regional decision-makers in applying and combining SPI tools.