In spite of the fact that regions and regional disparities have become important political issues inter-regional aspects are rarely addressed neither scientifically nor politically. The report provides an attempt to forecast economic and demographic changes within regions in England and how these changes will affect inter-regional relations. Thus, the report can also be regarded as a basis for regional planning over the next 25 years. The main goals of the report are, hence, to identify underlying forces in regional economies, describe how the relationships between regions have been changing and will change in the future, and develop a “national perspective” on England’s regions. It also explores the opportunities for policy intervention.